Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling
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چکیده
منابع مشابه
Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling.
The secreted protein Noggin1 is an embryonic inducer that can sequester TGFβ cytokines of the BMP family with extremely high affinity. Owing to this function, ectopic Noggin1 can induce formation of the headless secondary body axis in Xenopus embryos. Here, we show that Noggin1 and its homolog Noggin2 can also bind, albeit less effectively, to ActivinB, Nodal/Xnrs and XWnt8, inactivation of whi...
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ژورنال
عنوان ژورنال: Development
سال: 2011
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.068908